Nationality: Indian
Background: I graduated in 2025 with an integrated BS-MS degree from IISER Pune, with a major in Chemistry and a minor in Biology. My training combines organic synthesis, chemical biology, and analytical chemistry. Through research on enzyme-responsive small molecules and biomolecular systems, I developed a strong interest in molecular recognition and the design of selective materials for biomedical and diagnostic applications.
My research interests: Synthetic organic chemistry, analytical chemistry, phosphoproteomics, biomarker discovery, and the development of affinity materials for biomedical applications.
My PhD goals: To develop sequence-specific MIPs for the selective recognition and enrichment of phosphorylated peptide biomarkers associated with oncogenic signaling pathways. I aim to integrate these materials with mass spectrometry-based phosphoproteomic workflows to enable sensitive biomarker detection and advance precision medicine approaches.
My hobbies:Crocheting, Reading and Cinema
My project in MIPrecise: Molecularly imprinted polymers for phosphopeptide assays of oncogenic pathways
Master thesis: Design & Synthesis of Enzyme-activated HNO Donors and their NSAID Hybrids
HNO, the one-electron reduced congener of NO, exhibits significant therapeutic potential due to its cardioprotective, anticancer, and antioxidant properties. However, its highly unstable and reactive nature necessitates the use of donor molecules for controlled release. In this study, slow-releasing esterase-activated HNO donors were designed and synthesized to overcome the cytotoxicity observed in previous donors. Additionally, HNO-NSAID hybrids were developed to explore potential synergistic effects and to mitigate known NSAID side effects. The synthesized compounds were characterized, and their HNO release was evaluated alongside kinetic decomposition studies of the HNO-NSAID hybrid. The results demonstrated that the novel esterase-activated donors successfully released HNO, with the hybrid compound showing promising enzymatic activation, paving the way for further exploration of these molecules as therapeutic agents.