Project Description

The development of cancer-targeting diagnostics is the primary goal of the project, which is extensively integrated with other groups and DCs in the MIPrecise program. Specifically, the DC shall develop epitope imprinted nanoMIPs recognizing tumour specific antigens (e.g. EPCAM) in magnetic nanoMIP and fluorescent nanoMIP formats. The DC shall support MIP design with molecular modelling and undertake nanoMIP synthesis. Characterisation of nano-MIP–target affinities shall be explored using fluorescence and Quartz Crystal Microbalance (QCM)-based studies. The MIPs will be developed for use in CTC capture or labelling. The DC supervision shall be led by Prof Ian Nicholls together with Dr Gang Liu (Capitainer AB), Prof Edwin Schoof (DTU) and senior researchers in at Linnaeus University. DC7 shall provide support for integration of high affinity nanoMIPs in multiomics-based liquid biopsy targeted diagnostics. 

Supervisor information

Prof Ian A Nicholls
Department of Chemistry & Biomedical Sciences
Linnaeus University
SE-39182 Kalmar
Sweden

https://lnu.se/en/research/research-groups/bioorganic-and-biophysical-chemistry-laboratory/