Project Description
The aim of the PhD project is to design, synthesize and characterize nanoparticle MIPs (nanoMIPs) targeting cancer associated glycan motifs. Glycopeptides as model templates will be also synthesized. After characterization of the obtained nanoMIPs their affinity and selectivity for the templates will be assessed by novel analytical and spectroscopic methods. Then, the materials will be optimised in view of the development of MIP-based RNAseq of circulating tumor cells (CTCs) and of the development of fluorescent nanoMIPs, to obtain unique affinity tools filling a gap in targeted glycomics, cell capture and labelling.
Supervisor information
Professor Ersilia De Lorenzi
Department of Drug Sciences
University of Pavia
27100 Pavia
ITALY
Host Institution
Secondments
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Malmö University Sweden 1 month
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Linnaeus University Sweden 1 month
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Federal Institute for Materials Research and Testing Germany 1 month
-
Umeå University Sweden 1 months
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Proteome Sciences Germany 2 months
Degree awarding institution
- University of Pavia (Università degli Studi di Pavia), Italy
DC6 Isha Prabhu
