Project Description

The aim of the PhD project is to design, synthesize and characterize nanoparticle MIPs (nanoMIPs) targeting cancer associated glycan motifs. Glycopeptides as model templates will be also synthesized. After characterization of the obtained nanoMIPs their affinity and selectivity for the templates will be assessed by novel analytical and spectroscopic methods. Then, the materials will be optimised in view of the development of MIP-based RNAseq of circulating tumor cells (CTCs) and of the development of fluorescent nanoMIPs, to obtain unique affinity tools filling a gap in targeted glycomics, cell capture and labelling.

Other information

DC6 will be employed by the University of Pavia and based in the Department of Drug Sciences under the direct academic supervision of Professor Ersilia De Lorenzi. DC 6 will be enrolled in the PhD course in “Chemical and Pharmaceutical Sciences and Related Industrial Innovation” of the University of Pavia. The PhD title finally obtained will also bear the “Doctor Europaeus” label. DC6 will benefit from having experienced academic co-supervision from the Federal Institute for Materials Research and Testing (BAM, Berlin), intersectorial supervision at the University of Southern Denmark, as well as second academic supervisors in the Department of Drug Sciences. 

Supervisor information

Professor Ersilia De Lorenzi
Department of Drug Sciences
University of Pavia
27100 Pavia
ITALY

URL: https://scienzedelfarmaco.dip.unipv.it/en