Project Description

The aim of the PhD project is to design, synthesize and characterize nanoparticle MIPs (nanoMIPs) targeting cancer associated glycan motifs. Glycopeptides as model templates will be also synthesized. After characterization of the obtained nanoMIPs their affinity and selectivity for the templates will be assessed by novel analytical and spectroscopic methods. Then, the materials will be optimised in view of the development of MIP-based RNAseq of circulating tumor cells (CTCs) and of the development of fluorescent nanoMIPs, to obtain unique affinity tools filling a gap in targeted glycomics, cell capture and labelling.

Candidate requirements

We are seeking an outstanding, highly motivated doctoral candidate who meets the global MSCA criteria and who will bring the following to Pavia University: excellent Master’s degree in Analytical/Polymer/Organic/Medicinal/ Chemistry, Pharmacy, Bioanalytical protein/peptide Science or closely-related subject; problem-solving skills; intellectual curiosity; passion and enthusiasm; outstanding communication and interpersonal skills; commitment to outreach activities; honesty, reliability and integrity; time management skills.

Strong scientific writing and presentation skills in English are required. Evidence of proficiency in English must be provided at the time of application (normally, evidence of proficiency in the English language to at least level B1 of the Common European Framework of Reference for Languages -CEFR)

Previous experimental laboratory experience is mandatory and preference will be given to candidates:

– with hands-on experience on any of the following: HPLC, capillary electrophoresis, NMR, MS, fluorescence spectroscopy, DLS, IR.

– with hands-on experience in organic synthesis, including the ability to independently design and carry out reactions, perform work-up procedures, and isolate/purify the final products.

– with interdisciplinary experience directly related to the research topic of the position outlined above, notably molecularly imprinting technology, carbohydrates, peptides.

Basic knowledge of molecular or cell biology, particularly cell culture and cellular assays and competence in statistical analysis and data interpretation would be advantageous.

The applicant must hold a Master’s degree  (or any equivalent diploma) obtained by November 30 2025 and within the six years preceding this date. 

Other information

DC6 will be employed by the University of Pavia and based in the Department of Drug Sciences under the direct academic supervision of Professor Ersilia De Lorenzi. DC 6 will be enrolled in the PhD course in “Chemical and Pharmaceutical Sciences and Related Industrial Innovation” of the University of Pavia. The PhD title finally obtained will also bear the “Doctor Europaeus” label. DC6 will benefit from having experienced academic co-supervision from the Federal Institute for Materials Research and Testing (BAM, Berlin), intersectorial supervision at the University of Southern Denmark, as well as second academic supervisors in the Department of Drug Sciences. DC6 is expected to be appointed in February 2026.

Supervisor information

Professor Ersilia De Lorenzi
Department of Drug Sciences
University of Pavia
27100 Pavia
ITALY

Note: Application is through the official procedure on the site and NOT  via personal emails to the supervisor

URL: https://scienzedelfarmaco.dip.unipv.it/en