Project Description

Among several hundred protein PTMs the major part remains to be investigated at the proteome level. Although modification-specific enrichment techniques combined with MS/MS methods and data analysis have revealed a large extent of PTMs in proteins a lack of efficient affinity-based enrichment techniques causes several of the modifications to escape detection. This is the case of labile N-phosphorylations and methylations. This project will leverage state of the art imprinting techniques to develop refined polymer binders (porous polymers or nanoparticles) for such motifs compatible with peptide or protein affinity based assays.  These will be integrated in MIP-MS modification specific proteomics for mechanistic studies or as biomarker discovery tools, jointly with other partners.  

Supervisor information

Börje Sellergren, Professor in Biomedical Technology, Biofilms Research Center for Biointerfaces, Department of Biomedical Sciences, Malmö University.   

Phone: +46 40 665 7810

Mail: borje.sellergren@mau.se

URL: https://mau.se/en/research/research-centres/biofilms-research-centre-for-biointerfaces/