Project Description
At the University of Strathclyde in Glasgow, we have a keen interest in the design and synthesis of molecularly imprinted polymers (MIPs) and advanced affinity polymers that are able to capture protein and protein-derived (i.e., peptide) biomarkers of disease, as well as other biomarkers of disease, from complex biological fluids for the purposes of disease diagnosis, prognosis and monitoring. The primary task of the Strathclyde group in MIPrecise is to design, synthesize, and characterize novel organic polymers that have affinity and selectivity for cancer biomarkers and to work collaboratively with MIPrecise partners on the exploitation of the new polymers that are developed. In respect of the very aggressive disease of small cell lung cancer (SCLC), we wish to build upon and extend very successful collaborative work with the University of Oslo through the development of unique affinity tools that fill a gap in biomarker specific assays for SCLC and facilitate remote sampling.
A range of polymer formats will be targeted, including MIPs in physical formats that are optimised for the enrichment of low abundant peptides in state-of-the-art, miniaturized chemical separations, magnetic formats for magnetic capture platforms and trap columns. DC11 will be engaged primarily on research lines where the affinity and selectivity of the polymers arises through synthetic methodologies other than template-directed synthesis.
Supervisor information
Professor Peter Cormack
WestCHEM, Department of Pure and Applied Chemistry
University of Strathclyde
Thomas Graham Building
295 Cathedral Street
Glasgow, G1 1XL
Scotland, UK
Host Institution
Secondments
- Linnaeus University Sweden 1 month
- University of Pavia Italy 1 month
- University of Oslo Norway 1 month
- ReSyn Biosciences South Africa 1 month
- Capitainer AB Sweden 1 month
- Proteome Sciences Germany 1 month
Degree awarding institution
- University of Strathclyde UK