Project Description
DC10 will work with implementing Molecularly Imprinted Polymers (MIPs) in the sample preparation workflow of bottom-up liquid chromatography-mass spectrometry (LC-MS) analysis of established disease biomarkers. Novel MIP-assays developed in the project will be validated against conventional assays (including both immunoassays (where available) and MS-based assays). At UiO the candidate will focus on the determination of biomarkers for Small Cell Lung Cancer (SCLC), which is an aggressive form of lung cancer with a short survival after diagnosis (few months). Since SCLC is sensitive for treatment, early diagnosis or proper monitoring is of high interest. Our research focuses on design of the sample preparation and the possibility to determine and differentiate multiple SCLC markers simultaneously at ultra low concentrations which might allow a more robust and personalized diagnostic profile in the future.
Supervisor information
Trine Grønhaug Halvorsen and Léon Reubsaet
Section of Pharmaceutical Chemistry, Dept. of Pharmacy, University of Oslo, Oslo, Norway.
Host Institution
Secondments
- University of Strathclyde United Kingdom 3 months
- Proteome Sciences Germany 2 months
- Capitainer AB Sweden 1 month
Degree awarding institution
- University of Oslo Norway
DC10 Moritz Unnerstall
